Publications
Concept, neuroanatomy and surgical techniques
Neurophysiological studies at the cellular level (microelectrode unit activity recordings and local field potentials) as well as electro- and magnetoencephalographic recordings provide converging evidence for a thalamocortical dysregulation at the source of chronic neurogenic pain of both peripheral and central origin.
We simultaneously recorded local field potentials (LFP) in the thalamus and EEG on the scalp of 17 patients suffering from neurogenic pain, epilepsy and movement disorders. The EEG of 11 patients displayed enhanced power in the theta frequency range (4–8Hz). The thalamic LFP of 14 patients peaked in the theta range. The theta coherence between EEG and LFP was significant for 12 patients and reached strengths up to 70%. These findings suggest that enhanced theta rhythmicity occurs in tight functional thalamocortical loops and is a major element in all three diseases investigated.
After the questionable and inordinately wide application
of the prefrontal lobotomy in the first half of the twentieth century, many groups realized
the necessity of confining surgical interventions to the
paralimbic (or mesocortical) domain. This
gave rise to the three main stereotactic operations still in use
today
EEG techniques
Epilepsy, Tinnitus and Neuropsychiatry
Essential Tremor
Neurogenic Pain
While several mechanisms have been proposed for the pathophysiology of neurogenic pain, no general agreement has been reached yet. In the following we refer to a mechanism that focuses on thalamocortical interplay
We simultaneously recorded local field potentials (LFP) in the thalamus and EEG on the scalp of 17 patients suffering from neurogenic pain, epilepsy and movement disorders. The EEG of 11 patients displayed enhanced power in the theta frequency range (4–8Hz). The thalamic LFP of 14 patients peaked in the theta range. The theta coherence between EEG and LFP was significant for 12 patients and reached strengths up to 70%. These findings suggest that enhanced theta rhythmicity occurs in tight functional thalamocortical loops and is a major element in all three diseases investigated.
Excellent, focused evaluation of the surgical options available to the neurosurgeon. Highly recommended for practicing neurosurgeons interested in the field of pain management...
Parkinson
Investigation of sleep and sleep EEG before and after stereotactic neurosurgery.
Positive symptoms arise after lesions of the nervous system. They include neurogenic pain, tinnitus, abnormal movements, epilepsy and certain neuropsychiatric disorders.