Publications

Selected scientific articles and book chapters published in international litterature

Incisionless transcranial MR-guided focused ultrasound in essential tremor: cerebellothalamic tractotomy

15 February 2016

Read the full article here. Background Already in the late 1960s and early 1970s, targeting of the “posterior subthalamic area (PSA)” was explored by different functional neurosurgical groups applying the radiofrequency (RF) technique to treat patients suffering from essential tremor (ET). Recent advances in magnetic resonance (MR)-guided focused ultrasound (MRgFUS) technology offer the possibility to […]
Posted in:
Essential Tremor

Tagged with:
Cerebellothalamic tractotomy
Deep brain stimulation
Essential tremor
focused ultrasound
Functional neurosurgery
Gallay
Jeanmonod
Magara
Moser
thalamotomy
Multiarchitectonic and stereotactic atlas of the human thalamus.

7 September 2015

To improve anatomical definition and stereotactic precision of thalamic targets in neurosurgical treatments of chronic functional disorders, a new atlas of the human thalamus has been developed. This atlas is based on multiarchitectonic parcellation in sections parallel or perpendicular to the standard intercommissural reference plane. The calcium-binding proteins parvalbumin (PV), calbindin D-28K (CB), and calretinin […]
Posted in:
Concept
Neuroanatomy

Tagged with:
atlas
basal ganglia
brain mapping
Jeanmonod
Magnin
Morel
thalamus
Book Chapter: The Central Lateral Thalamotomy for Neuropathic Pain.

7 September 2015

In: Textbook of Stereotactic and Functional Neurosurgery. Lozano A., Gildenberg P. (eds.). Springer-Verlag: Berlin, Chapter 123, pp. 2081-2096, 2009. Read a part of this chapter on Google Books
Posted in:
Neurogenic Pain

Tagged with:
central lateral thalamotomy
Jeanmonod
stereotaxy
thalamocortical system
First experience with MR-guided focused ultrasound in the treatment of Parkinson’s disease

20 May 2014

Background Radiofrequency (RF) subthalamotomies have been proposed since the 1960s to treat patients suffering from Parkinson’s disease (PD). Recently, the magnetic resonance (MR)-guided focused ultrasound technology (MRgFUS) offers the possibility to perform subthalamic thermocoagulations with reduced risks and optimized accuracy. We describe here the initial results of the MRgFUS pallidothalamic tractotomy (PTT), an anatomical […]
Posted in:
Parkinson
Technical

Tagged with:
fields of Forel
focused ultrasound
Magara
MRI
Pallidothalamic tractotomy
MR-guided focused ultrasound technique in functional neurosurgery: targeting accuracy

25 April 2013

Background The purpose of this study was to describe targeting accuracy in functional neurosurgery using incisionless transcranial magnetic resonance (MR)-guided focused ultrasound technology. Methods MR examinations were performed before and 2 days after the ultrasound functional neurosurgical treatment to visualize the targets on T2-weighted images and determine their coordinates. Thirty consecutive targets were reconstructed: 18 were […]
Posted in:
Technical

Tagged with:
accuracy
atlas
focused ultrasound
Moser
MRI
surgery
Cognitive functioning, emotional processing, mood, and personality variables before and after stereotactic surgery: a study of 8 cases with chronic neuropathic pain

23 April 2013

BACKGROUND: Stereotactic central lateral thalamotomy (CLT) has been applied as a treatment for chronic intractable neuropathic pain. However, it is not clear whether this intervention influences the emotional and cognitive impairments observed in patients who have chronic neuropathic pain. OBJECTIVE: To investigate neuropsychological functions and emotional processing in patients with chronic neuropathic pain compared with […]
Posted in:
Concept
Neurogenic Pain

Tagged with:
focused ultrasound
neurocognition
Pirotta
surgery
thalamus
Measurement of targeting accuracy in focused ultrasound functional neurosurgery

3 January 2012

The object of this study was to describe a method of measuring targeting accuracy in functional neurosurgery using MR imaging and the Stereotactic Atlas of the Human Thalamus and Basal Ganglia. This method should be useful for any functional procedure using these tools or similar ones, and is described here in the specific context of […]
Posted in:
Technical

Tagged with:
accuracy
atlas
focused ultrasound
Moser
MRI
surgery
Transcranial magnetic resonance imaging-guided focused ultrasound: noninvasive central lateral thalamotomy for chronic neuropathic pain.

3 January 2012

OBJECT: Recent technological developments open the field of therapeutic application of focused ultrasound to the brain through the intact cranium. The goal of this study was to apply the new transcranial magnetic resonance imaging-guided focused ultrasound (tcMRgFUS) technology to perform noninvasive central lateral thalamotomies (CLTs) as a treatment for chronic neuropathic pain. METHODS: In 12 […]
Posted in:
Neurogenic Pain

Tagged with:
central lateral thalamotomy
focused ultrasound
Jeanmonod
MRI
surgery
Correlations between EEG and clinical outcome in chronic neuropathic pain: surgical effects and treatment resistance.

27 September 2011

Chronic neuropathic pain may require a neurosurgical treatment, but for reasons that have not been fully explored yet, a significant number of patients do not benefit from the intervention. We compared the resting EEG of 15 healthy controls to the EEG of 23 chronic neuropathic pain patients before and 12 months after treatment by the […]
Posted in:
EEG
Neurogenic Pain

Tagged with:
central lateral thalamotomy
frustration
localization
Michels
surgery
treatment resistance
A computational model of thalamocortical dysrhythmia

13 December 2010

Functional stereotactic lesions in the central lateral nucleus of the medial thalamus have proved to be an effective treatment of neurogenic pain and other neurological disorders associated with thalamocortical dysrhythmia. The mechanisms underlying patient recovery after surgery are currently being explored using quantitative electroencephalography. Here we test the hypothesis that the particular role played by […]
Posted in:
Concept
Technical

Tagged with:
bursts
Proske
thalamocortical system
Does greater low frequency EEG activity in normal immaturity and in children with epilepsy arise in the same neuronal network?

20 August 2010

Greater low frequency power (<8 Hz) in the electroencephalogram (EEG) at rest is normal in the immature developing brain of children when compared to adults. Children with epilepsy also have greater low frequency interictal resting EEG activity. Whether these power elevations reflect brain immaturity due to a developmental lag or the underlying epileptic pathophysiology is […]
Posted in:
EEG
Epilepsy

Tagged with:
localization
Michels
Temporo-insular enhancement of EEG low and high frequencies in patients with chronic tinnitus. QEEG study of chronic tinnitus patients.

24 March 2010

BACKGROUND: The physiopathological mechanism underlying the tinnitus phenomenon is still the subject of an ongoing debate. Since oscillatory EEG activity is increasingly recognized as a fundamental hallmark of cortical integrative functions, this study investigates deviations from the norm of different resting EEG parameters in patients suffering from chronic tinnitus. RESULTS: Spectral parameters of resting EEG […]
Posted in:
EEG
Tinnitus

Tagged with:
dysrhythmia
localization
Moazami
power correlation

Publications

Selected scientific articles and book chapters published in international litterature

Incisionless transcranial MR-guided focused ultrasound in essential tremor: cerebellothalamic tractotomy

Multiarchitectonic and stereotactic atlas of the human thalamus.

Book Chapter: The Central Lateral Thalamotomy for Neuropathic Pain.

First experience with MR-guided focused ultrasound in the treatment of Parkinson’s disease

MR-guided focused ultrasound technique in functional neurosurgery: targeting accuracy

Cognitive functioning, emotional processing, mood, and personality variables before and after stereotactic surgery: a study of 8 cases with chronic neuropathic pain

Measurement of targeting accuracy in focused ultrasound functional neurosurgery

Transcranial magnetic resonance imaging-guided focused ultrasound: noninvasive central lateral thalamotomy for chronic neuropathic pain.

Correlations between EEG and clinical outcome in chronic neuropathic pain: surgical effects and treatment resistance.

A computational model of thalamocortical dysrhythmia

Does greater low frequency EEG activity in normal immaturity and in children with epilepsy arise in the same neuronal network?

Temporo-insular enhancement of EEG low and high frequencies in patients with chronic tinnitus. QEEG study of chronic tinnitus patients.

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Recent Publications

Incisionless transcranial MR-guided focused ultrasound in essential tremor: cerebellothalamic tractotomy

Multiarchitectonic and stereotactic atlas of the human thalamus.